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THIS IS A PAPERBACK EDITION FOR THE EXPORT MARKET. OVER 2 MILLION COPIES SOLD * #1 INTERNATIONAL BESTSELLER * USA TODAY BESTSELLER * WALL STREET JOURNAL BESTSELLER Improve all areas of your health from your sleep, cravings, mood, energy, skin, weight, and even slow down aging, with "simple and accessible science-based hacks" (Michael Mosley, MD, #1 New York Times bestselling author of The Fast Diet) to manage your glucose levels while still eating the foods you love. Glucose, or blood sugar, is a tiny molecule in our body that has a huge impact on our health. It enters our bloodstream through the starchy or sweet foods we eat. Ninety percent of us suffer from too much glucose in our system-and most of us don't know it. The symptoms? Cravings, fatigue, infertility, hormonal issues, acne, wrinkles. And over time, the development of conditions like type 2 diabetes, polycystic ovarian syndrome, cancer, dementia, and heart disease. Drawing on cutting-edge science and her own pioneering research, biochemist Jessie Inchauspé offers ten simple, surprising hacks to help you balance your glucose levels and reverse your symptoms-without going on a diet or giving up the foods you love. For example: -What small change to your breakfast will unlock energy and cut your cravings -How eating foods in the right order will make you lose weight effortlessly -What secret ingredient will allow you to eat dessert and still go into fat-burning mode Both entertaining, informative, and packed with the latest scientific data, this book presents a new way to think about better health. Full of tips that can drastically and immediately improve your life, whatever your dietary preferences, Glucose Revolution is "the best practical guide for managing glucose to maximize health and longevity" (David Sinclair, PhD, New York Times bestselling author).

How much control do we have over love? Much less than we like to think. All that mystery, all that poetry, all those complex behaviors sur­rounding human bonding leading to the most life-changing decisions we'll ever make, are unconsciously driven by a few molecules in our brains. How does love begin? How can two strangers come to the conclusion that it would not only be pleasant to share their lives, but that they must share them? How can a man say he loves his wife, yet still cheat on her? Why do others stay in relationships even after the ro­mance fades? How is it possible to fall in love with the "wrong” person? How do people come to have a "type”? Physical attraction, jealousy, infidelity, mother-infant bonding—all the behaviors that so often leave us befuddled—are now being teased out of the fog of mystery thanks to today's social neuroscience. Larry Young, one of the world's leading experts in the field, and journalist Brian Alexander explain how those findings apply to you. Drawing on real human stories and research from labs around the world, The Chemistry Between Us is a bold attempt to create a "grand unified theory” of love. Some of the mind-blowing insights include: Love can get such a grip on us because it is, literally, an addiction. To a woman falling in love, a man is like her baby. Why it's false to say society makes gender, and how it's possible to have the body of one gender and the brain of another. Why some people are more likely to cheat than others. Why we sometimes truly can't resist temptation. Young and Alexander place their revelations into historical, political, and social contexts. In the pro­cess, they touch on everything from gay marriage to why single-mother households might not be good for society. The Chemistry Between Us offers powerful in­sights into love, sex, gender, sexual orientation, and family life that will prove to be enlightening, contro­versial, and thought provoking.

Natürliche Unterstützung für die Leber Eine gesunde, voll funktionsfähige Leber ist für den gesamten Organismus sehr wichtig. Mit einem Gewicht von ca.1,4-1,8 kg das schwerste Organ und die größte Drüse des menschlichen Körpers und ein wichtiges Stoffwechselorgan. Verschiedene Faktoren können die Funktion der Leberzellen stören, darunter insbesondere Genussgifte wie Alkohol, übermäßig zucker- und fetthaltige Nahrung sowie bestimmte Medikamente. Silymarin STADA® 156 mg Hartkapseln, ein Trockenextrakt aus Mariendistelfrüchten, schützt und regt die Neubildung von Leberzellen an.* * Federico A, Dallio M, Loguerico C. Silymarin/Silybin and Chronic Liver Disease: a marriage of many years. Molecules 2017, 22, 191; doi:10.3390/molecules22020191 Anwendung: Nehmen Sie dieses Arzneimittel immer genau wie in der Packungsbeilage beschrieben ein. Fragen Sie bei Ihrer Ärztin, Ihrem Arzt oder in Ihrer Apotheker nach, wenn Sie sich nicht sicher sind. Die empfohlene Dosis beträgt: Erwachsene 2-mal täglich 1 Hartkapsel (Mariendistelfrüchte-Trockenextrakt entsprechend 156 mg Silymarin). Inhaltsstoffe Der Wirkstoff ist: Mariendistelfrüchte-Trockenextrakt standardisiert auf Silymarin. 1 Hartkapsel enthält 239,6 - 294,9 mg Trockenextrakt aus gereinigten Mariendistelfrüchten (36 - 44:1) entsprechend 156 mg Silymarin (berechnet als Silibinin, HPLC); Auszugsmittel: Ethylacetat. Die sonstigen Bestandteile sind: Mikrokristalline Cellulose, Maisstärke, Poly(O-carboxymethyl)stärke-Natriumsalz, Natriumdodecylsulfat, Magnesiumstearat (Ph.Eur.) [pflanzlich], Gelatine, Titandioxid (E 171), Eisen(III)-oxid (E 172), Gereinigtes Wasser. Wie Silymarin STADA® 156 mg Hartkapseln aussehen und Inhalt der Packung Rötlichbraun-elfenbeinfarbene Hartkapseln Silymarin STADA® 156 mg Hartkapseln ist in Packungen mit 30 oder 100 Hartkapseln erhältlich. HÄUFIGE FRAGEN & ANTWORTEN Beeinflusst die Einnahme von Silymarin STADA® 156 mg Hartkapseln die Verkehrstüchtigkeit und Fähigkeit zum Bedienen von Maschinen? Silymarin STADA® 156 mg Hartkapseln hat keinen oder einen zu vernachlässigenden Einfluss auf die Verkehrstüchtigkeit und die Fähigkeit zum Bedienen von Maschinen. Einnahme von Silymarin STADA® 156 mg Hartkapseln zusammen mit anderen Arzneimitteln Informieren Sie Ihren Arzt oder Apotheker, wenn Sie andere Arzneimittel einnehmen, kürzlich andere Arzneimittel eingenommen haben oder beabsichtigen, andere Arzneimittel einzunehmen. Untersuchungen mit Silymarin STADA® 156 mg Hartkapseln mit anderen Arzneimitteln liegen nicht vor. Dürfen schwangere oder stillende Frauen Silymarin STADA® 156 mg Hartkapseln einnehmen? Silymarin STADA® 156 mg Hartkapseln darf in der Schwangerschaft nicht eingenommen werden. Silymarin STADA® 156 mg Hartkapseln soll wegen nicht ausreichender Untersuchungen in der Stillzeit nicht eingenommen werden. Es liegen keine Erkenntnisse zur Auswirkung von Silymarin STADA® 156 mg Hartkapseln auf die Fertilität vor. Silymarin STADA® 156 mg Hartkapseln Zur Anwendung bei Erwachsenen Wirkstoff: Mariendistelfrüchte-Trockenextrakt standardisiert auf Silymarin. Angewendet zur unterstützenden Behandlung bei chronisch-entzündlichen Lebererkrankungen, Leberschrumpfung (Leberzirrhose) und durch Lebergifte verursachte (toxische) Leberschäden. Das Arzneimittel ist nicht zur Behandlung von akuten Vergiftungen bestimmt. Zu Risiken und Nebenwirkungen lesen Sie die Packungsbeilage und fragen Sie Ihre Ärztin, Ihren Arzt oder in Ihrer Apotheke. STADA Consumer Health Deutschland GmbH, Stadastraße 2–18, 61118 Bad Vilbel Stand: April 2024

OVER 2 MILLION COPIES SOLD * #1 INTERNATIONAL BESTSELLER * USA TODAY BESTSELLER * WALL STREET JOURNAL BESTSELLER Improve all areas of your health from your sleep, cravings, mood, energy, skin, weight, and even slow down aging, with “simple and accessible science-based hacks” (Michael Mosley, MD, #1 New York Times bestselling author of The Fast Diet) to manage your glucose levels while still eating the foods you love. Glucose, or blood sugar, is a tiny molecule in our body that has a huge impact on our health. It enters our bloodstream through the starchy or sweet foods we eat. Ninety percent of us suffer from too much glucose in our system—and most of us don’t know it. The symptoms? Cravings, fatigue, infertility, hormonal issues, acne, wrinkles. And over time, the development of conditions like type 2 diabetes, polycystic ovarian syndrome, cancer, dementia, and heart disease. Drawing on cutting-edge science and her own pioneering research, biochemist Jessie Inchauspé offers ten simple, surprising hacks to help you balance your glucose levels and reverse your symptoms—without going on a diet or giving up the foods you love. For example: -What small change to your breakfast will unlock energy and cut your cravings -How eating foods in the right order will make you lose weight effortlessly -What secret ingredient will allow you to eat dessert and still go into fat-burning mode Both entertaining, informative, and packed with the latest scientific data, this book presents a new way to think about better health. Full of tips that can drastically and immediately improve your life, whatever your dietary preferences, Glucose Revolution is “the best practical guide for managing glucose to maximize health and longevity” (David Sinclair, PhD, New York Times bestselling author).

Frontmatter -- Preface -- Contents -- I. A HISTORICAL NOTE -- Two thousand years of fibrinogen research and evidence for fibrin being the first protein -- II. GENE ANALYSIS -- Fibrinogen evolution - The structure and evolution of fibrinogen: The coiled coil region -- Absence of gross defect of fibrinogen genes in one patient with congenital afibrinogenemia -- III. FIBRINOGEN-FIBRIN CONVERSION -- Fibrinogen to fibrin - an overview -- Fibrin - specific monoclonal antibodies are elicited by immunization with a synthetic fibrin-like peptide -- Enhancement of fibrin polymerization by active site - inhibited thrombin -- Peptides released from human fibrinogen by thrombic enzymes -- The analysis of fibrinopeptide release from S--carboxymethylated fibrinogen chains using high-performance liquid chromatography -- Moaification of the fibrin a-chain by dipeptidyl peptidase IV -- IV. FIBRINOGEN-FIBRIN INTERACTION -- Analysis of composition of soluble fibrinogen/fibrin complexes by differential ultracentrifugation -- Reversible interactions of fibrin and fibrinogen: an ultracentrifugation study -- V. NORMAL FIBRINOGEN VARIANTS -- Evidence that the amount of heparin precipitable fraction is influenced by fibrinogen quality -- The location of a second in vivo phosphorylation site in the Aa-chain of human fibrinogen -- Evidence that the y chain population of human platelet fibrinogen lacks the y' variant that is present in plasma fibrinogen -- Differences and similarities between human adult and fetal fibrinogen fragments D1 -- VI. ABNORMAL FIBRINOGEN VARIANTS -- Functional defects in abnormal fibrinogens -- Study of 10 cases of congenital dysfibrinogenemia: clinical and molecular biological aspects -- Fibrinogens Sydney I and II, a kinetic study of (His16 )FPA cleavage and its effect on FPB cleavage -- Fibrinogens London I - IV, Manchester, Sydney I and II. Cleavage of fibrinopeptides by thrombin and expression of their polymerisation abnormalities -- Aspects of evaluation of fibrinogen Stony Brook - A defect resulting in failure to release fibrinopeptide A -- Fibrinogen Tokyo II: An abnormal fibrinogen with an impaired polymerization site on the aligned DD domain of fibrin molecules -- Fibrinogen Milan II: A congenital dysfibrinogenemia with a defective clotting by thrombin, normal clotting by arvin, reptilase and prothrombin-staphy1ocoagulase complex, associated with thrombotic episodes -- Preliminary report concerning two new cases of congenital dysfibrinogenemia (Homburg II and Homburg III) -- The effect of sodium citrate on fibrin polymerisation in patients with liver disease -- VII. FIBRINOGEN DEGRADATION PRODUCTS -- Studies of the proteolytic fragments of the C-terminal portion of the a-chain of human fibrinogen -- Biodistribution or human fibrinogen-derived peptides in rabbits -- Structure-function studies on a vasoactive pentapeptide derived from plasm in degradation of human fibrin(ogen) -- Purification and characteristics of a vasoactive peptide derived from elastase degradation of human fibrin(ogen) -- Relation of crosslinked to non crosslinked fibrin derivatives in tumor ascites compared to cirrhosis ascites -- VIII. INTERACTION WITH PLASMINOGEN AND ITS ACTIVATOR -- Study of the interaction between plasminogen and fibrinogen degradation products using immunoenzymological assay -- Fibrin and plasminogen structures involved in the tissue-type plasminogen activator catalyzed activation of plasminogen -- Kinetics of the tissue-type plasminogen activatormediated activation of plasminogen. Influence of CNBr fibrin(ogen) fragment FCB-2 and different forms of plasminogen -- IX. INTERACTION WITH CELLS -- Structural characterization of the recognition site for platelet receptors on human fibrinogen -- Binding or fibrinogen to ADP-treated platelets: Importance of the A?-chain -- Inhibition of fibrinogen binding to activated platelets by oligoamines -- Specific interaction between fibrinogen-fibrin and endothelial cells -- Influence of fibr

【Double-sided textured GECO printing plate naming design】In 2025, JUUPINE launched a new cold plate designed for PLA printing and named it GECO. As the name suggests, it allows the print to cling to the plate like a gecko. The GECO surface is specially made with a frosted texture. When the filament touches it, it makes full use of the subtle force between molecules-van der Waals force, to build countless stable microscopic connections, so that the print is firmly formed and tightly "adsorbed" on it like a gecko. 【Compatible models】Applicable to Creality K2 Plus 3D printer heated bed platform, double-sided printing (370 x 370 mm). 【Thickened and heavier】Our GECO hot bed is thicker and heavier than ordinary PEI hot beds. Thickened and magnetic, it can prevent large prints from warping and small and tall prints from tipping over. Flexible, detachable, double-sided design. Durable and easy to use, place the printing platform on the hot bed of the K2 PLUS 3D printer and debug after turning it on. The spring steel plate can be bent, and the model can be quickly removed without the help of other tools, and the platform can be leveled again. [Excellent adhesion of the first layer of printing] The model can be firmly attached to the GECO surface, and even beginners can print easily. With excellent adhesion, it can exert excellent viscosity at room temperature above 0 degrees, without heating the platform. When printing at 0 degrees Celsius or room temperature, less power consumption can complete the printing task, bid farewell to glue and handwriting marks, and save the cumbersome printing process. [Daily maintenance and use are easier] Before printing, you can use alcohol and soapy water to clean the printing platform, remove dust, degrease and remove handwriting marks, and then use it directly. [For PLA] The surface of GECO is not resistant to high temperatures, and heating is prohibited during printing. Only PLA special consumables can be printed. Only for PLA materials. Do not use the original default temperature of PLA. The sheet slicing temperature must not exceed 40 degrees Celsius.

The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered. It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.

The biological world operates on a multitude of scales - from molecules to cells to tissues to organisms to ecosystems. Throughout all these levels runs a common thread: the communication and onward passage of information - from cell to cell, from organism to organism and, ultimately, from generation to generation. But how does this information - no more than a static repository of data - come alive to govern the processes that constitute life? The answer lies in the concerted action of molecular components which cooperate through a series of carefully-regulated processes to bring the information in our genome to life. These components and processes lie at the heart of one of the most fascinating subjects to engage the minds of scientists today: molecular biology. Molecular Biology: Principles of Genome Function offers a fresh, distinctive approach to the teaching of molecular biology. It is an approach that reflects the challenge of teaching a subject that is in many ways unrecognizable from the molecular biology of the 20th century - a discipline in which our understanding has advanced immeasurably, but about which many questions remain to be answered. It is written with several guiding themes in mind: - A focus on key principles provides a robust conceptual framework on which students can build a solid understanding of the discipline; - An emphasis on the commonalities that exist between the three kingdoms of life, and the discussion of differences between the three kingdoms where such differences offer instructive insights into molecular processes and components, gives students an accurate depiction of our current understanding of the conserved nature of molecular biology, and the differences that underpin biological diversity; - An integrated approach demonstrates how certain molecular phenomena have diverse impacts on genome function by presenting them as themes that recur throughout the book, rather than as artificially separated topics At heart, molecular biology is an experimental science, and a central element to the understanding of molecular biology is an appreciation of the approaches taken to yield the information from which concepts and principles are deduced. Yet there is also the challenge of introducing the experimental evidence in a way that students can readily comprehend. Molecular Biology responds to this challenge with Experimental Approach panels, which branch off from the text in a clearly-signposted way. These panels describe pieces of research that have been undertaken, and which have been particularly valuable in elucidating different aspects of molecular biology. Each panel is carefully cross-referenced to the discussion of key molecular biology tools and techniques, which are presented in a dedicated chapter at the end of the book. Beyond this, Molecular Biology further enriches the learning experience with full-colour, custom-drawn artwork; end-of-chapter questions and summaries; relevant suggested further readings grouped by topic; and an extensive glossary of key terms. Among the students being taught today are the molecular biologists of tomorrow; these individuals will be in a position to ask fascinating questions about fields whose complexity and sophistication become more apparent with each year that passes. Molecular Biology: Principles of Genome Function is the perfect introduction to this challenging, dynamic, but ultimately fascinating discipline.