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The ultimate illustrated guide to elephants and their prehistoric relativesToday, only three species of elephants survive-the African savanna elephant (Loxodonta africana), the African forest elephant (Loxodonta cyclotis), and the Asian elephant (Elephas maximus). However, these modern giants represent just a fraction of the vast and diverse order Proboscidea, which includes not only living elephants but also their many extinct relatives. Over the past 60 million years, proboscideans have evolved and adapted across five continents, giving rise to an astonishing variety of forms, from the massive, woolly-coated mammoths of the Ice Age to the diminutive, island-dwelling dwarf elephants. This book offers a comprehensive exploration of proboscidean biology and evolutionary history, shedding light on the remarkable diversity of these extraordinary mammals. It delves into the anatomical characteristics of every known species, from the towering steppe mammoth (Mammuthus trogontherii) and the shovel-tusked Amebelodon to the semi-aquatic Moeritherium and the enigmatic Deinotherium. Readers will discover how these creatures developed an array of specialized adaptations, including variations in tusk shape and function, highly flexible trunks suited for different feeding strategies, and unique dental structures that allowed them to process a wide range of vegetation. Accompanied by stunning illustrations by Shu-yu Hsu, Elephants and Their Fossil Relatives brings these ancient giants back to life, offering a visually captivating and scientifically rigorous journey through their evolutionary past. Whether you are a paleontology enthusiast, a student of evolutionary biology, or a researcher in the field, this book serves as an indispensable reference for understanding one of the most extraordinary groups of animals ever to walk the earth. Brings together all known elephant species and their fossil relatives in a single volume for the first timeCovers more than 230 extinct species ranging in size from creatures no larger than a chihuahua to colossal giants weighing up to three times the mass of modern elephantsFeatures hundreds of stunning full-color illustrations and cutting-edge 3D reconstructions-many restored for the first timeDelves into the biology and behavior of modern elephants, answering key questions about their anatomy, behavior, and profound impact on human cultureDraws on groundbreaking studies of ancient proteins, isotopes, and DNAA must-have for elephant lovers everywhere

The ultimate illustrated guide to elephants and their prehistoric relativesToday, only three species of elephants survive-the African savanna elephant (Loxodonta africana), the African forest elephant (Loxodonta cyclotis), and the Asian elephant (Elephas maximus). However, these modern giants represent just a fraction of the vast and diverse order Proboscidea, which includes not only living elephants but also their many extinct relatives. Over the past 60 million years, proboscideans have evolved and adapted across five continents, giving rise to an astonishing variety of forms, from the massive, woolly-coated mammoths of the Ice Age to the diminutive, island-dwelling dwarf elephants. This book offers a comprehensive exploration of proboscidean biology and evolutionary history, shedding light on the remarkable diversity of these extraordinary mammals. It delves into the anatomical characteristics of every known species, from the towering steppe mammoth (Mammuthus trogontherii) and the shovel-tusked Amebelodon to the semi-aquatic Moeritherium and the enigmatic Deinotherium. Readers will discover how these creatures developed an array of specialized adaptations, including variations in tusk shape and function, highly flexible trunks suited for different feeding strategies, and unique dental structures that allowed them to process a wide range of vegetation. Accompanied by stunning illustrations by Shu-yu Hsu, Elephants and Their Fossil Relatives brings these ancient giants back to life, offering a visually captivating and scientifically rigorous journey through their evolutionary past. Whether you are a paleontology enthusiast, a student of evolutionary biology, or a researcher in the field, this book serves as an indispensable reference for understanding one of the most extraordinary groups of animals ever to walk the earth. Brings together all known elephant species and their fossil relatives in a single volume for the first timeCovers more than 230 extinct species ranging in size from creatures no larger than a chihuahua to colossal giants weighing up to three times the mass of modern elephantsFeatures hundreds of stunning full-color illustrations and cutting-edge 3D reconstructions-many restored for the first timeDelves into the biology and behavior of modern elephants, answering key questions about their anatomy, behavior, and profound impact on human cultureDraws on groundbreaking studies of ancient proteins, isotopes, and DNAA must-have for elephant lovers everywhere

[FLOOR MATTRESS] - Thickness: 8-10cm/3-3.9in. Shikibuton is a traditional Japanese floor mattress that is also known as a futon. The quilted pattern is made very delicately. The borders of the mattress are hemmed to make it more structured and intact. The floor mattress has 8 sizes,japanese style futons are typically soft,foldable,rollable and portable,meeting your different needs [STRUCTURE FILLING] - This twin futon mattress is made up of soybean protein fiber cotton+high-density base support foam as the inner layer. Our mattress pad performs well in long-lasting durability,good flexibility and deformation resistance,thus ensuring pressure-relieving and comfortable sleeping experience. The ventilated polyester fabric cover is designed to promote air circulation and avoid sultry heat [FOLDABLE PORTABLE] - Japanese floor mattress is a versatile option to meet your needs to sleep with vast flexibility. You can use it as a futon in the bedroom, a pet bed, a yoga mat, a tatami mat, a sleeping floor mat, a tent mat, a kids' play mat, a guest mattress, or a living room futon. This foldable mattress is suitable for both adults and children uses and you to take it to car trips or camping excursions [PARCEL SHIPPING] - In order to allow you to pick up the package as independently and conveniently as possible and transportation,our mattresses are delivered to you in a vacuum-sealed compressed form. Upon receiving your cotton futon mattress,it's important to give a few days time to fully expand to its original thickness. Periodically turning over and rotating a mattress to prevent body impressions [EASY CARE] - You will get 1 Mattress,1 Mattress Cover. Japanese Floor Mattress is a practical and easy-to-use sleeping solution. You can start using the mattress right after unboxing and can be matched with various styles of bedrooms. The removable mattress cover keeps dust away from the mattress. When necessary,simply remove the cover to wash in the washing machine

Examining the enormous potential of microbiome manipulation to improve health Associations between the composition of the intestinal microbiome and many human diseases, including inflammatory bowel disease, cardiovascular disease, metabolic disorders, and cancer, have been elegantly described in the past decade. Now, whole-genome sequencing, bioinformatics, and precision gene-editing techniques are being combined with centuries-old therapies, such as fecal microbiota transplantation, to translate current research into new diagnostics and therapeutics to treat complex diseases. Bugs as Drugs provides a much-needed overview of microbes in therapies and will serve as an excellent resource for scientists and clinicians as they carry out research and clinical studies on investigating the roles the microbiota plays in health and disease. In Bugs as Drugs, editors Robert A. Britton and Patrice D. Cani have assembled a fascinating collection of reviews that chart the history, current efforts, and future prospects of using microorganisms to fight disease and improve health. Sections cover traditional uses of probiotics, next-generation microbial therapeutics, controlling infectious diseases, and indirect strategies for manipulating the host microbiome. Topics presented include: * How well-established probiotics support and improve host health by improving the composition of the intestinal microbiota of the host and by modulating the host immune response. * The use of gene editing and recombinant DNA techniques to create tailored probiotics and to characterize next-generation beneficial microbes. For example, engineering that improves the anti-inflammatory profile of probiotics can reduce the number of colonic polyps formed, and lactobacilli can be transformed into targeted delivery systems carrying therapeutic proteins or bioengineered bacteriophage. * The association of specific microbiota composition with colorectal cancer, liver diseases, osteoporosis, and inflammatory bowel disease. The gut microbiota has been proposed to serve as an organ involved in regulation of inflammation, immune function, and energy homeostasis. * Fecal microbiota transplantation as a promising treatment for numerous diseases beyond C. difficile infection. Practical considerations for using fecal microbiota transplantation are provided, while it is acknowledged that more high-quality evidence is needed to ascertain the importance of strain specificity in positive treatment outcomes. Because systems biology approaches and synthetic engineering of microbes are now high-throughput and cost-effective, a much wider range of therapeutic possibilities can be explored and vetted.

This edition is heavily outdated and we have a new edition with PyTorch examples published! Key Features: - Code examples are in TensorFlow 2, which make it easy for PyTorch users to follow along - Look inside the most famous deep generative models, from GPT to MuseGAN - Learn to build and adapt your own models in TensorFlow 2.x - Explore exciting, cutting-edge use cases for deep generative AI Book Description: Machines are excelling at creative human skills such as painting, writing, and composing music. Could you be more creative than generative AI? In this book, you'll explore the evolution of generative models, from restricted Boltzmann machines and deep belief networks to VAEs and GANs. You'll learn how to implement models yourself in TensorFlow and get to grips with the latest research on deep neural networks. There's been an explosion in potential use cases for generative models. You'll look at Open AI's news generator, deepfakes, and training deep learning agents to navigate a simulated environment. Recreate the code that's under the hood and uncover surprising links between text, image, and music generation. What You Will Learn: - Export the code from GitHub into Google Colab to see how everything works for yourself - Compose music using LSTM models, simple GANs, and MuseGAN - Create deepfakes using facial landmarks, autoencoders, and pix2pix GAN - Learn how attention and transformers have changed NLP - Build several text generation pipelines based on LSTMs, BERT, and GPT-2 - Implement paired and unpaired style transfer with networks like StyleGAN - Discover emerging applications of generative AI like folding proteins and creating videos from images Who this book is for: This is a book for Python programmers who are keen to create and have some fun using generative models. To make the most out of this book, you should have a basic familiarity with math and statistics for machine learning. Table of Contents - An Introduction to Generative AI: "Drawing" Data from Models - Setting up a TensorFlow Lab - Building Blocks of Deep Neural Networks - Teaching Networks to Generate Digits - Painting Pictures with Neural Networks using VAEs - Image Generation with GANs - Style Transfer with GANs - DeepFakes with GANs - The Rise of Methods for Text Generation - NLP 2.0: Using Transformers to Generate Text - Composing Music with Generative Models - Play Video Games with Generative AI: GAIL - Emerging Applications in Generative AI

***Ace Your Exam and Get the Results You Deserve*** Taking the Certified Strength and Conditioning Specialist(R)* Exam is a challenge and your results can make a huge difference when it comes to your future. If you do well on the exam, it can open doors and lead to wonderful opportunities. If you do poorly on the exam, you will find yourself with fewer options. You may have to put your plans for the future on hold, or even give up on them altogether. Preparing for your exam with our Flashcard Study System for the CSCS(R)* Exam can help you avoid this fate and give you a big advantage when you take the test. Thousands of satisfied customers have relied on Mometrix Flashcards to help them pass their exams, and now you can too. * CSCS(R) and Certified Strength and Conditioning Specialist(R) are registered trademarks of the National Strength and Conditioning Association. Neither this publication nor the publisher have any affiliation with, or any recognition, sponsorship, or endorsement by, the NSCA. When you study with Mometrix CSCS flashcards, you'll get an in-depth review of each test section. The Exercise Science section includes: * Muscle fiber * Protein myosin * Joints * Blood lactate * Electrocardiogram The Nutrition section includes: * DRI system * Electrolytes * Cell turnover * Anorexia nervosa and bulimia nervosa * EPO The Exercise Technique section includes: * Autogenic inhibition * Mechanoreceptors * Dynamic stretching * Hold-relax with agonist contraction The Program Design section includes: * SAID * Long-term planning * Complex training model * Stretch-shortening cycle * Sprinting The Organization and Administration section includes: * Feasibility study * Liability * Negligence * Eligibility criteria The Testing and Evaluation section includes: * Testing segments * Aerobic capacity/power * Difference score ...and much more! We believe in delivering lots of value for your money, so our flashcard system is packed with the critical information you'll need to master in order to ace your CSCS exam. Our flashcards enable you to study small, digestible bits of information that are easy to learn and give you exposure to the different question types and concepts. With Mometrix flashcards, you'll be able to study anywhere, whenever you have a few free minutes of time. Study after study has shown that spaced repetition is the most effective form of learning, and nothing beats flashcards when it comes to making repetitive learning fun and fast. Using Mometrix flashcards for your CSCS review incorporates repetitive methods of study to teach you how to break apart and quickly solve difficult test questions. You also get online access to CSCS practice test questions, created by our Mometrix test prep team, to prepare you for what to expect on the actual exam. Each answer is explained in depth, in order to make the principles and reasoning behind it crystal clear. Mometrix Test Preparation has helped thousands of people achieve their education goals. Our Flashcard Study System for the CSCS(R) Exam can help you get the results you deserve on your CSCS test too.

Knowledge graphs help understand relationships between the objects, events, situations, and concepts in your data so you can readily identify important patterns and make better decisions. This book provides tools and techniques for efficiently labeling data, modeling a knowledge graph, and using it to derive useful insights. In Knowledge Graphs and LLMs in Action you will learn how to: • Model knowledge graphs with an iterative top-down approach based in business needs • Create a knowledge graph starting from ontologies, taxonomies, and structured data • Use machine learning algorithms to hone and complete your graphs • Build knowledge graphs from unstructured text data sources • Reason on the knowledge graph and apply machine learning algorithms Move beyond analyzing data and start making decisions based on useful, contextual knowledge. The cutting-edge knowledge graphs (KG) approach puts that power in your hands. In Knowledge Graphs and LLMs in Action, you’ll discover the theory of knowledge graphs and learn how to build services that can demonstrate intelligent behavior. You’ll learn to create KGs from first principles and go hands-on to develop advisor applications for real-world domains like healthcare and finance. Purchase of the print book includes a free eBook in PDF and ePub formats from Manning Publications. About the technology Knowledge graphs represent a network of real-world entities—from people and places to genes and proteins—and model the relationships between them. KGs represent a real paradigm shift in the way that machines can understand data by effectively modeling the contextual information that’s vital for human knowledge. They’re poised to help revolutionize data analysis and machine learning, with applications ranging from search engines to e-commerce and more. About the book Knowledge Graphs and LLMs in Action is a practical guide to putting knowledge graphs into action. It’s full of techniques and code samples for building and analyzing knowledge graphs, all demonstrated with serious full-sized datasets. Throughout the book, you’ll find extensive examples and use-cases taken from healthcare, biomedicine, document archive management systems, and even law enforcement. You’ll learn methodologies based on the very latest KG approaches, as well as deep learning graph techniques such as Graph Neural Networks and NLP-based tools like BERT. About the reader For readers who know the basics of machine learning. Examples in Python. About the author Dr. Alessandro Negro is the Chief Scientist at GraphAware. Alessandro has been a speaker at many prominent conferences and is the author of the Manning book Graph-Powered Machine Learning and several scientific publications. He is one of the creators of GraphAware Hume, a mission critical knowledge graph platform. Dr. Vlastimil Kus is the Lead Data Scientist at GraphAware where he contributes to the development of Hume. Over the years he has gained significant experience in building and utilizing Knowledge Graphs from unstructured data using NLP and ML techniques in various domains. His current focus is NLP and Graph Machine Learning. Dr. Giuseppe Futia is Senior Data Scientist at GraphAware and a Fellow at the Nexa Center for Internet & Society. He holds a Ph.D. in computer engineering from the Politecnico di Torino (Italy), where he explored Graph Representation Learning techniques to support the automatic building of Knowledge Graphs. Fabio Montagna is the Lead Machine Learning Engineer at GraphAware. He holds a master’s degree in software engineering from Unisalento (Italy). As a bridge between science and industry, he assists with moving rapidly from scientific reasoning to product value.

Das WERK: »From Clones to Claims« has evolved as a reaction to the ready internet availability of all decisions of the Boards of Appeal of the European Patent Office (EPO). While the increased availability is one thing, using the information in daily practice is another. This translation is the aim of the 7th edition of this book. It has become a guide through the available decisions not only of Boards 3.3.04 and 3.3.08 – the initial biotech Boards – but also of Boards 3.3.01 and 3.3.02, which have meanwhile also begun to hear biotech cases. This reflects the overwhelming development and expansion of biotech into the field of biopharmaceuticals, for example, the advent of antibody drugs against several types of life-threatening cancer and chronic diseases, such as rheumatoid arthritis. One of the best current examples of the importance of biopharmaceuticals was the virtually immediate advent of powerful vaccines against the causative agent of the corona (SARS-CoV-2/Covid-19) pandemic. »From Clones to Claims« contains extra chapters on the patenting of viruses – and related vaccines. This is just one example of the chapters in the expanded version. This 7th edition also contains other supplemental chapters in view of recent developments in science and related jurisprudence. For example, new or substantially revised chapters include a new, more elaborate chapter on SPCs; a new chapter on plausibility, with express consideration of pending case G 2/21; as well as new chapters on next generation sequencing technologies and personalized medicines/ companion diagnostics. A further new chapter addresses CRISPR, outlining and discussing the complex pattern of oppositions and appeals in the EPO concerning this revolutionary, Nobel prize winning technology. Thus, the current jurisprudence of the Boards of Appeal of the EPO is systematically organized according to the following topics: • Products of Nature: What is Patentable in the EPO (compounds, stem cells, plants, etc.) • The Person Skilled in the Art • The Principles Applied by the Technical Boards in Assessing the Disclosure of a Document and their Implications • The Principles Applied by the Technical Boards in Claim Construction • Plausibility as a Means to Assess Quid Pro Quo • The Principles of Patenting Medical and Diagnostic Uses • Patenting Nucleic Acid Inventions • Patenting Protein Inventions • Patenting Antibody Inventions • Patenting Microorganisms and Fermentation Technologies • Patenting Viruses • Patenting Stem Cells and Cell-based Therapeutics • Patenting Nucleic Acid Amplification Technologies • Patenting Nucleic Acid Modification Technologies: CRISPR et al. • Patenting Next Generation Sequencing Technologies • Patenting Personalized Medicines and Companion Diagnostics • Patenting Plants and Animals • Priority – Hurdles of Same Subject Matter and Legal Entitlement • Deposit • How to draft a European Patent Application and Claims • A Brief Introduction to the Extension of Patent Terms As is evident, this expanded version of »From Clones to Claims« solely focuses on EPO Appeal Board jurisprudence and SPCs. It no longer addresses jurisprudence from the US or Japan as a consequence of the technically limited space in such a product. Thus, the new version is a detailed guide on how to prepare European patent applications in any particular field of biopharmaceuticals and how to best defend the European patents once granted. Given this, the book is not only useful for advanced practitioners, but also for beginners as an introduction into and an orientation to the field of biotechnology patents. Given the book‘s clear language and systematic structure, the EPO‘s jurisprudence is immediately accessible for specific areas of daily practice. For instance, if the question arises as to what extent stem cells, viruses, vaccines, antibodies or plants can be claimed and how enablement, novelty and inventive step of such claims are routinely assessed by the EPO, separate specialized

Das WERK: »From Clones to Claims« has evolved as a reaction to the ready internet availability of all decisions of the Boards of Appeal of the European Patent Office (EPO). While the increased availability is one thing, using the information in daily practice is another. This translation is the aim of the 7th edition of this book. It has become a guide through the available decisions not only of Boards 3.3.04 and 3.3.08 – the initial biotech Boards – but also of Boards 3.3.01 and 3.3.02, which have meanwhile also begun to hear biotech cases. This reflects the overwhelming development and expansion of biotech into the field of biopharmaceuticals, for example, the advent of antibody drugs against several types of life-threatening cancer and chronic diseases, such as rheumatoid arthritis. One of the best current examples of the importance of biopharmaceuticals was the virtually immediate advent of powerful vaccines against the causative agent of the corona (SARS-CoV-2/Covid-19) pandemic. »From Clones to Claims« contains extra chapters on the patenting of viruses – and related vaccines. This is just one example of the chapters in the expanded version. This 7th edition also contains other supplemental chapters in view of recent developments in science and related jurisprudence. For example, new or substantially revised chapters include a new, more elaborate chapter on SPCs; a new chapter on plausibility, with express consideration of pending case G 2/21; as well as new chapters on next generation sequencing technologies and personalized medicines/ companion diagnostics. A further new chapter addresses CRISPR, outlining and discussing the complex pattern of oppositions and appeals in the EPO concerning this revolutionary, Nobel prize winning technology. Thus, the current jurisprudence of the Boards of Appeal of the EPO is systematically organized according to the following topics: Products of Nature: What is Patentable in the EPO (compounds, stem cells, plants, etc.) The Person Skilled in the Art The Principles Applied by the Technical Boards in Assessing the Disclosure of a Document and their Implications The Principles Applied by the Technical Boards in Claim Construction Plausibility as a Means to Assess Quid Pro Quo The Principles of Patenting Medical and Diagnostic Uses Patenting Nucleic Acid Inventions Patenting Protein Inventions Patenting Antibody Inventions Patenting Microorganisms and Fermentation Technologies Patenting Viruses Patenting Stem Cells and Cell-based Therapeutics Patenting Nucleic Acid Amplification Technologies Patenting Nucleic Acid Modification Technologies: CRISPR et al. Patenting Next Generation Sequencing Technologies Patenting Personalized Medicines and Companion Diagnostics Patenting Plants and Animals Priority – Hurdles of Same Subject Matter and Legal Entitlement Deposit How to draft a European Patent Application and Claims A Brief Introduction to the Extension of Patent Terms As is evident, this expanded version of »From Clones to Claims« solely focuses on EPO Appeal Board jurisprudence and SPCs. It no longer addresses jurisprudence from the US or Japan as a consequence of the technically limited space in such a product. Thus, the new version is a detailed guide on how to prepare European patent applications in any particular field of biopharmaceuticals and how to best defend the European patents once granted. Given this, the book is not only useful for advanced practitioners, but also for beginners as an introduction into and an orientation to the field of biotechnology patents. Given the book‘s clear language and systematic structure, the EPO‘s jurisprudence is immediately accessible for specific areas of daily practice. For instance, if the question arises as to what extent stem cells, viruses, vaccines, antibodies or plants can be claimed and how enablement, novelty and inventive step of such claims are routinely assessed by the EPO, separate specialized chapters of the book can be consulted. NE

Knowledge graphs help understand relationships between the objects, events, situations, and concepts in your data so you can readily identify important patterns and make better decisions. This book provides tools and techniques for efficiently labeling data, modeling a knowledge graph, and using it to derive useful insights. In Knowledge Graphs and LLMs in Action you will learn how to: Model knowledge graphs with an iterative top-down approach based in business needs Create a knowledge graph starting from ontologies, taxonomies, and structured data Use machine learning algorithms to hone and complete your graphs Build knowledge graphs from unstructured text data sources Reason on the knowledge graph and apply machine learning algorithms Move beyond analyzing data and start making decisions based on useful, contextual knowledge. The cutting-edge knowledge graphs (KG) approach puts that power in your hands. In Knowledge Graphs and LLMs in Action, you’ll discover the theory of knowledge graphs and learn how to build services that can demonstrate intelligent behavior. You’ll learn to create KGs from first principles and go hands-on to develop advisor applications for real-world domains like healthcare and finance. Purchase of the print book includes a free eBook in PDF and ePub formats from Manning Publications. About the technology Knowledge graphs represent a network of real-world entities—from people and places to genes and proteins—and model the relationships between them. KGs represent a real paradigm shift in the way that machines can understand data by effectively modeling the contextual information that’s vital for human knowledge. They’re poised to help revolutionize data analysis and machine learning, with applications ranging from search engines to e-commerce and more. About the book Knowledge Graphs and LLMs in Action is a practical guide to putting knowledge graphs into action. It’s full of techniques and code samples for building and analyzing knowledge graphs, all demonstrated with serious full-sized datasets. Throughout the book, you’ll find extensive examples and use-cases taken from healthcare, biomedicine, document archive management systems, and even law enforcement. You’ll learn methodologies based on the very latest KG approaches, as well as deep learning graph techniques such as Graph Neural Networks and NLP-based tools like BERT. About the reader For readers who know the basics of machine learning. Examples in Python. About the author Dr. Alessandro Negro is the Chief Scientist at GraphAware. Alessandro has been a speaker at many prominent conferences and is the author of the Manning book Graph-Powered Machine Learning and several scientific publications. He is one of the creators of GraphAware Hume, a mission critical knowledge graph platform. Dr. Vlastimil Kus is the Lead Data Scientist at GraphAware where he contributes to the development of Hume. Over the years he has gained significant experience in building and utilizing Knowledge Graphs from unstructured data using NLP and ML techniques in various domains. His current focus is NLP and Graph Machine Learning. Dr. Giuseppe Futia is Senior Data Scientist at GraphAware and a Fellow at the Nexa Center for Internet & Society. He holds a Ph.D. in computer engineering from the Politecnico di Torino (Italy), where he explored Graph Representation Learning techniques to support the automatic building of Knowledge Graphs. Fabio Montagna is the Lead Machine Learning Engineer at GraphAware. He holds a master’s degree in software engineering from Unisalento (Italy). As a bridge between science and industry, he assists with moving rapidly from scientific reasoning to product value.